Systematic Review and Meta-analysis Workshop

Using Review Manager software (SRMA)

Who should attend?

This course provides a detailed explanation of the methods of qualitative and quantitative evidence synthesis, using a practical approach to teach the steps of systematic review and meta-analysis for clinical researchers. The course is suitable for clinical researchers on all academic levels: (Master's students, PhD students, Faculty members, Clinicians, Pharmacists, Independent researchers).

* Undergraduate students (beyond their 2nd year) who are interested in research can participate.

Intended learning objective (ILOs)

By the end of this course, the participant should be able to:

1-Identify a relevant research question for systematic review project

2-Determine the PICO of his research question and state the inclusion/exclusion criteria

3-Search the literature systemically, remove duplicate publications, and screen records

4-Assess the quality of randomized controlled trials using the Cochrane risk of bias assessment tool

5-Make summary and baseline characteristics tables of the systematic review

6-Interpret forest plots (effect size/heterogeneity)

7-Make data extraction sheet for meta-analysis

8-Calculate missing data for performing a meta-analysis

9-Perform a meta-analysis model on Review Manager software

11- Interpretation of forest plot

12- Choosing statistical method and outcome measure

13- Pooling continuous and categorical outcomes in meta-analysis model

14- Assessing and Resolving heterogeneity

15- Subgroup analysis and Sensitivity analysis

16- Assessment of Publication bias and interpretation of Funnel plot.

Workshop 5: You will be given some excel sheets including data derived from published randomized controlled trials. Each team will be work together to pool these data in the meta-analysis model on RevMan. The team will be asked to interpret the findings and comment on the heterogeneity.

Workshop 6: The same as previous example. Then, make sensitivity analysis to resolve the present heterogeneity. Then, comment on the findings "How to report the findings of sensitivity analysis on your research paper?".

Workshop 7: The same as previous workshop. Then, make subgroup analysis according to the duration of treatment.

Workshop 8: The same as previous workshop. Then make the funnel plot to assess the publication bias. Then, comment on the findings "How to report the findings of sensitivity analysis on your research paper?".

6- Quality assessment of interventional studies using Cochrane ROB tool

7- How to construct baseline characteristics table

8- Generating PRISMA flow diagram and Risk of Bias graph & summary

9- Standard reporting of Systematic reviews [PRISMA checklist domains]

10- Introduction to Meta-analysis

Workshop 2: work in mini teams to assess the quality of three randomized controlled trials according to the Cochrane Risk of Bias assessment tool. Then, make the ROB graph and summary of RevMan software.

Workshop 3: work in mini teams to make the table of baseline characteristics of systematic review involving the same previously mentioned 3 RCTs.

Workshop 4: Each team will be given a forest plot. Work in mini teams to interpret the effect size in the forest plots (significant/not significant).

1- Why Systematic reviews?

2- Types of Systematic reviews

3- Steps of Systematic reviews

4- How to search the literature, export results & check duplications [Using Zotero/ Endnote]

5- How to screen abstracts [Covidence]

Workshop 1: work in mini teams to develop a research question, state your PICO and keywords, and formulate the inclusion/exclusion criteria.

Course syllabus


  • Attendants should bring their laptops on all days
  • Attendants should have a prior knowledge about (Research Designs, Clinical Trials, Descriptive Statistics, and Inferential Statistics)
  • Download Zotero standalone and browser plugin:
  • Download EndNote trial version:
  • Make an account on Covidence:

Review Manager software

There are many softwares that can perform meta-analysis models. This workshop will run on the Review Manager (RevMan) software. The workshop organizers will help you to download the software.

Download link:

Workshop Instructor

Mr. Ahmed Negida

Ahmed Negida is a final year medical student (MBBCh candidate) who is involved in clinical research since his second year in the medical school. He is collaborating with many researchers in Egypt and worldwide. He is a well-known expert in clinical research designing, medical statistics, scientific writing, and evidence synthesis. He acts as a reviewer and editor in many international journals.

To the moment, he has >40 international research publications with total citations >240 and H-index>7. In his spare time, he gives research workshops to researchers and doctors. Since 2014, he has taught >700 researchers through his workshops in different Egyptian governorates and universities.

Recent workshops of the lecturer during 2016

  • 4-7 September 2016: Research Methodology Course at Department of Global Health Affairs, American University of Cairo.
  • 16-24 March 2016: Systematic Review and Meta-analysis workshop at Faculty of Medicine, Suez Canal University, Egypt

Recent systematic review and Meta-analysis publications during 2016

  • Ahmed, H., Elgebaly, A., Abushouk, A. I., Hammad, A. M., Attia, A., & Negida, A. (2016). Safety and efficacy of sofosbuvir plus ledipasvir with and without ribavirin for chronic HCV genotype-1 infection: a systematic review and meta-analysis. Antiviral therapy.‏
  • Elgebaly, A., Menshawy, A., El Ashal, G., Osama, O., Ghanem, E., Omar, A., & Negida, A. (2016). Sunitinib alone or in combination with chemotherapy for the treatment of advanced breast cancer: A systematic review and meta-analysis. Breast Disease, (Preprint), 1-11.‏
  • Negida, A., Menshawy, A., El Ashal, G., Elfouly, Y., Hani, Y., Hegazy, Y., ... & Rashad, Y. (2016). Coenzyme Q10 for Patients with Parkinson's Disease: A Systematic Review and Meta-Analysis. CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS & Neurological Disorders), 15(1), 45-53.‏
  • Elgebaly, A., Abdelazeim, B., Mattar, O., Gadelkarim, M., Salah, R., & Negida, A. (2016). Meta-analysis of the safety and efficacy of droxidopa for neurogenic orthostatic hypotension. Clinical Autonomic Research, 1-10.‏

Workshop References

  • Higgins JPT, Green S (2008) Cochrane handbook for systematic reviews of interventions. Wiley Online Library
  • Liberati A, Altman DG, Tetzlaff J, et al (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. Ann Intern Med 151:W-65.
  • Moher D, Liberati A, Tetzlaff J, Altman DG (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 6:e1000097. doi: 10.1371/journal.pmed.1000097
  • Owens DK, Lohr KN, Atkins D, et al Methods Guide for Comparative Effectiveness Reviews. Rockville, MD Agency Healthc. Res. Qual.
  • Whitlock EP, Lopez SA Methods Guide for Comparative Effectiveness Reviews.

Our next workshops

You can see the list of our upcoming workshops on the following links:


And here:

If you are interested in hosting this workshop in your institution, contact us on: